Oprah brings together doctors and weight loss patients who discuss their journeys and the rise in weight loss drugs in a new special.

The TV legend gets candid about her weight loss journey and brings in experts to discuss the health implications of the medications she used to help reach her goals.

Winfrey revealed in December that she takes a prescription drug for weight loss.

In tonight’s “An Oprah Special: Shame, Blame and the Weight Loss Revolution” on ABC, she sits down with medical experts and everyday people who are using prescription drugs to find their way to health.

Dr. Alok Patel previews Oprah Winfrey’s prime-time special on weight loss, including the medications helping many Americans achieve their own health goals.

WW's shares dropped more than 20% on Thursday in the aftermath of the media mogul's announcement.

Shares in WeightWatchers dropped by 25% after Oprah Winfrey announced that she has decided not to stand for re-election at the annual meeting of shareholders in May.

Oprah Winfrey celebrated Quinta Brunson's historic Emmys win by sending a massive bouquet of flowers to the "Abbott Elementary" set.

Oprah Winfrey has confirmed she is on a weight loss medication and says she no longer believes her weight struggles are her fault.

Tory Johnson is here with some exclusive offers on products from brands such as Amelia Rose Jewelry, Laura Geller Beauty and more.

Winfrey spoke about the years of shame she says she experienced for her weight.

The two stars announced a $10 million donation as part of the launch of the People's Fund of Maui to help those devastated by the recent wildfires.

Oprah Winfrey and Dwayne Johnson have teamed up to establish the People's Fund of Maui to help those affected by the recent wildfires.

Oprah handed out pillows and other supplies to people at a shelter and Amazon's Jeff Bezos and fiancée Lauren Sanchez are establishing a $100 million fund to help Maui get back on its feet.

In an inspiring commencement speech, Oprah told graduating seniors at Tennessee State University to be good "to at least one other person every single day."

Oprah Winfrey shared a tribute to her late father, Vernon Winfrey, who died July 8 at the age of 88.

"Oprahdemics" takes a look back at some memorable moments from the iconic daytime talk show that made an impact on culture and beyond.

In honor of her birthday, we compiled some of our favorite Oprah moments.

The star television host said that this year she wanted to support people from around the country who use their creativity to create unique products.

Winfrey confirmed earlier this year that the magazine's December 2020 issue would be its last monthly print edition.

Tory Johnson shows viewers the best in travel organization, truffle hot sauces, drinkware and food bags on the go as well as functional fashion just in time for Black Friday holiday shopping.

She brought together critical thinkers and action-takers to talk about race in America. ABC News' Will Ganss has the highlights.

The donation will assist organizations in places close to her heart: her hometown of Kosciusko, Mississippi, Chicago, Nashville, Milwaukee and Baltimore.

While the class of 2020 may not be able to participate in the commencement celebrations they expected, some virtual events are giving this year's graduates a star-studded send off.

In true Oprah fashion, Oprah Winfrey posted an inspirational commencement speech for the Class of 2020.

Oprah Winfrey's commencement speech to the class of 2020: "To be the class that commenced a new way forward," she said, "bravo."

Oprah Winfrey took part in Facebook's "#Graduation2020: Celebrate the class of 2020" ceremony to help raise spirits.

The former talk show host will curate the four-week program. "Together, let’s reset, refocus, and find clarity in what matters most," she said.

And yes, one of them was the book Meghan read to him in his birthday video.

Facebook and Instagram are throwing a virtual graduation for the class of 2020, including a commencement address from Oprah Winfrey and a performance by Miley Cyrus.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Christina Koch marked a historic first for the longest space mission for a woman aboard the International Space Station

For Oprah’s "2020 Vision: Your Life in Focus" tour, the grand dame of self-love has recruited some famous friends to join her and spread the good word.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

One Morehouse student now has a brand new iPhone -- thanks to Oprah Winfrey.

"If we had married, we would not be together,'” she said of her partner.

Oprah Winfrey is continuing to give back to HBCUs in a major way.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Dr. Jennifer Ashton takes a closer look at how a shot can prevent sickness.

Oprah Winfrey recently said she "would love to" do a talk show again, just not everyday.

Oprah Winfrey is hinting at the possibility of reviving her iconic talk show, "The Oprah Winfrey Show."

"I'm dedicated to her happiness," Graham revealed.

Brie Larson is a renown actress with millions of fans across the globe, but even she still gets a little starstruck sometimes.

The 10th Annual Women in the World Summit began Wednesday night and what better self-made icon to kick things off than Oprah Winfrey.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

Lara Spencer reports the buzziest stories of the day in "GMA" Pop News.

The TV icon talked about the emotional final days with her mother, who passed away on Thanksgiving Day.

She went home twice to make sure she said all she needed to before her death.

The media mogul spoke out late Monday after news of her mother's death.